EFFICACY AND SAFETY OF LIPID-LOWERING THERAPIES IN COMBINATION WITH OR WITHOUT STATIN TO REDUCE THE CARDIOVASCULAR RISK: A SYSTEMATIC REVIEW OF RANDOMISED CONTROLLED TRIALS

Background and aims: Cardiovascular diseases (CVD) pose a significant global health burden.Lowering low-density lipoprotein-cholesterol is the primary therapeutic aim for preventing primary and secondary CVD events.While statins are the standard treatments, their limitations, such as side effects and intolerance in certain patient groups, necessita

Background Since the outbreak of the COVID-19 pandemic, multiple efforts of modelling of the geo-temporal transmissibility of the virus have been undertaken, but none describes the pandemic spread at the global level.The aim of this research is to provide a high-resolution global model of the pandemic that overcomes the problem of biased country-le

Captive Psittaciformes may harbor Gram-negative bacteria in their digestive tract, mainly due to poor hygienic conditions and confinement.The present study was carried out with the objective of isolating and identifying Escherichia coli in samples collected from Psittaciformes cages in 50 commercial establishments in the metropolitan region of Goia

Abstract Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as a critical intermediary.This review delineates the intricate pathways leading to mtDNA release, Pedal Set which include membrane permeabilization, vesicular trafficking, disruption of homeostatic regulation, and abnormalities i